Abstract
Cisplatin is one of the most effective chemotherapeutic agents used in the treatment of malignancies. The clinical use of cisplatin is limited by its severe adverse effects. Acute or long term cardiotoxicity is the most important doselimiting toxicity of cisplatin Cases of angina, myocardial infarction, and atrial arrhythmia have been reported during continuous infusion of cisplatin, but atrioventricular block (AV) has not been reported. Herein, we report a case with recurrent AV block that developed during cisplatin infusion, for the first time.
Highlights
Atrioventricular (AV) block can be defined as a delay or interruption in the transmission of an impulse from the atria to the ventricles, and can be transient or permanent
Myocardial infarction, and atrial arrhythmia have been reported during continuous infusion of cisplatin, but AV block has not been reported
The patient has no history of cardiac disease or disorders, and was not administered cardiovascular medication that changes AV conduction, nearly
Summary
Atrioventricular (AV) block can be defined as a delay or interruption in the transmission of an impulse from the atria to the ventricles, and can be transient or permanent. It has been reported many causes for AV block including drugs, electrolyte disturbances, infiltrative malignancies, hyperthyroidism, and rheumatologic disorders. Myocardial infarction, and atrial arrhythmia have been reported during continuous infusion of cisplatin, but AV block has not been reported.
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