Abstract
BackgroundKikuchi Fujimoto disease (KFD), or histiocytic necrotising lymphadenitis, is a benign and self-limiting condition characterised by primarily affecting the cervical lymph nodes. Recurrent aseptic meningitis in association with KFD is extremely rare and remains a diagnostic challenge.Case presentationWe report a 28-year-old man who presented 7 episodes of aseptic meningitis associated with KFD over the course of 7 years. Histopathological findings of enlarged lymph nodes led to the diagnosis of KFD. The patient’s headache and lymphadenopathy spontaneously resolved without any sequelae.ConclusionsA diagnosis of KFD should be considered when enlarged cervical lymph nodes are observed in patients with recurrent aseptic meningitis. A long-term prognosis remains uncertain, and careful follow-up is preferred.
Highlights
Kikuchi Fujimoto disease (KFD), or histiocytic necrotising lymphadenitis, is a benign and self-limiting condition characterised by primarily affecting the cervical lymph nodes
The most common neurological complication is aseptic meningitis, which is observed in 2.8-9.8% of KFD cases [4,5]
* Correspondence: tkoma@dokkyomed.ac.jp 1Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321-0293, Japan Full list of author information is available at the end of the article this study, we describe a KFD patient who presented with 7 episodes of recurrent meningitis
Summary
Kikuchi-Fujimoto disease (KFD), or histiocytic necrotising lymphadenitis, is recognised as a benign lymphadenopathy that has acute or sub-acute onset and is primarily localised within the cervical lymph nodes. Laboratory analysis revealed no abnormalities in the patient’s complete blood cell count or liver and thyroid function tests. His serum CRP and IgE levels were elevated, measuring 2.5 mg/dL (normal,
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