Abstract
Recurrent aphthous stomatitis (RAS) is a rather widespread oral ulcerative condition with an unclear etiology. The clinical characteristics of RAS have been defined and therapies include anesthetic gel, oral anti-inflammatory drugs, Vitamin B12 supplements and corticosteroid ointment used on the lips. However, these approaches have not been rigorously evaluated. Persistent and painful RAS was successfully treated with 4% Power Fucoidan Cream TM (PFC, Daiichi-Sangyo, Osaka, Japan) in two women. RAS was remarkably improved by PFC. Further clinical trials are needed to confirm the value and safety of topical PFC for treating RAS.
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