Recurrent Acute Kidney Injury in Renal Transplant Patients: A Single-Center Study

Abstract

ObjectiveRenal transplant patients may have recurrent episodes of acute kidney injury (AKI) during the posttransplant period. Determination and management of risk factors may help to prevent recurrence of AKI and allograft loss. In this study, we investigated the clinical features of renal transplant patients with recurrent AKI and evaluated etiologies and risk factors. Materials and MethodsA total of 19 patients with 79 AKI episodes were examined retrospectively. AKI classes, etiologies, and risk factors were investigated. Their features were compared with 38 renal transplant patients without AKI. ResultsDistribution of AKI episodes according to the type of injury was as follows: 15 prerenal, 43 renal, 6 postrenal, and 15 mixed. Renal transplant patients with recurrent AKI had a greater duration of dialysis before transplantation (P < .05). Logistic regression analysis revealed no predictor for recurrent AKI after renal transplantation. Infections participated in the development of 45 AKI episodes. Chronic kidney disease developed in 16 patients. ConclusionInfections are the leading condition associated with recurrent AKI in renal transplant patients. Recurrent AKI may contribute to the development and progression of chronic kidney injury.