Abstract
ObjectiveThis study aimed to systematically investigate and compare the post-treatment recurrence of intraosseous ameloblastoma in patients treated with conservative or aggressive approaches.MethodsSystemic searches of PubMed, Medline, Cochrane Library, and Embase databases from inception to October 28, 2020, were conducted. Studies that aimed to evaluate the recurrence of intraosseous ameloblastoma by conservative and aggressive treatment approaches were included.ResultsA total of 20 studies with 942 ameloblastoma cases were included. Fourteen studies included patients with ameloblastoma who received conservative treatment, and 16 studies reported the overall recurrence rate for patients undergoing aggressive treatment. The pooled results indicated that the recurrence rate for aggressive treatment [0.12, 95% confidence interval (CI) = 0.09–0.16] was significantly lower than that for conservative treatment, with a recurrence rate of 0.30 (95% CI = 0.23–0.39). Similar results were obtained when stratifying the participants by the histological classification. When trying stratification analysis following the original included studies, multicystic ameloblastoma presented a much higher recurrence rate than solid and unicystic ameloblastomas.ConclusionThese findings supported the hypothesis that aggressive treatment might lead to a lower recurrence rate than conservative treatment. More studies and meta-analyses following the new histological classification of ameloblastomas are needed to validate and support the findings.
Highlights
Ameloblastomas are benign but locally invasive neoplasms that represent 10% of all jaw tumors [1]
The pooled results indicated that the recurrence rate for aggressive treatment [0.12, 95% confidence interval (CI) = 0.09–0.16] was significantly lower than that for conservative treatment, with a recurrence rate of 0.30
Similar results were obtained when stratifying the participants by the histological classification
Summary
Ameloblastomas are benign but locally invasive neoplasms that represent 10% of all jaw tumors [1]. They are characterized by slow growth, asymptomatic swelling and/or perforation of the cortical bone. Without any treatment, ameloblastomas might grow into massive proportions, causing facial deformity [2]. Surgery is deemed to be one of the major treatment approaches for ameloblastomas, and resection is considered an ideal surgical method [3]. With aggressive treatment and the current standard of care, a high degree of morbidity is observed and the risk of recurrence still exists [4]. Recurrent ameloblastoma is difficult to be treated, especially if it recurs in an anatomical region with limited surgical access or is detected in a later stage
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
