Abstract
Given that colon cancer is one of the most prevalent cancers worldwide, it is essential to employ strategies to try to reduce its incidence and recurrence rate. Though colon cancer is a sporadic disease in the vast majority of cases, multiple risk factors are linked to this disease, namely, obesity and cigarette smoking. Additionally, not many studies have been done in Saudi Arabia studying the recurrence rate of colon cancer. Therefore, we conducted a retrospective cohort study at King Khalid Hospital, King Abdulaziz Medical City, National Guard Health Affairs (NGHA), Jeddah, Saudi Arabia to investigate the recurrence rate of colon cancer in patients treated with complete colon resection followed by chemotherapy versus patients treated with colon resection alone via electronic and paper medical records. A total of 120 patients were included in this study; 61 were males (50.8%) and 59 were females (49.2%). According to our findings, the recurrence rate in patients who underwent surgical resection with adjuvant chemotherapy was 15.6% (n = 10), while the recurrence rate in patients with surgery alone was 21.4% (n = 12). Cancer recurrence is associated with significant morbidity and mortality. Therefore, further studies should be done to investigate the recurrence rate in patients with risk factors to identify and deal with the causes of recurrence.
Highlights
Colon cancer is a cancerous tumor arising from the inner wall of the large intestine
The most common risk factor related to colon cancer in this research was obesity (n = 17; 14.1%), followed by smoking (n = 10; 8.3%) (Figure 1)
We found that 64 patients (53.3%) underwent surgical resection followed by chemotherapy, while 56 patients (46.7%) underwent surgery alone
Summary
Colon cancer is a cancerous tumor arising from the inner wall of the large intestine (colon). It starts as noncancerous small clusters of cells called polyps on the inside wall of the colon [1]. Some of the benign polyps can become cancerous It is the most common type of gastrointestinal tumors worldwide. In Saudi Arabia, it is the most common cancer among men and the third among women [2]. It can happen at any age, it usually affects older adults (above 50). Many factors may increase the risk of colon cancer, such as older age (over 50), African-American race, a personal or family history of colon cancer or polyps, chronic inflammatory diseases of the colon, such as ulcerative colitis and Crohn’s disease, low-fiber or high-fat diet, smoking, alcoholism, and obesity [3]
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