Recurrence Pattern of Cervical Cancer Based on the Platinum Sensitivity Concept: A Multi‐Institutional Study from the FRANCOGYN Group

Abstract

Background: The standard of care for patients with advanced cervical cancer (ACC) includes platinum-based chemotherapy. The concept of platinum sensitivity is a major prognostic factor for patients with ovarian cancer. The aim of this study was to validate the applicability of the platinum sensitivity concept to ACC patients, and to estimate its prognostic interest in term of Overall Survival (OS) and pattern of recurrence (location, timing). Methods: Data of women with histologically proven FIGO 2019 stages IB3-IV ACC treated between May 2000 and November 2017 with platinum based regimens were retrospectively abstracted from 12 institutions from the FRANCOGYN Group. Findings: Respective 3-year OS were 52% (95% CI: 40·8-66·8), 21·6% (95% CI: 12·6-37·2) and 14·6% (95% CI: 4·2-50·2), in case of recurrence 18 months (p<0·001). In multivariate analysis, platinum sensitivity status was a strong prognostic factor for OS after recurrence. Interpretation: Platinum-sensitivity status may help to classify recurrent patients in three prognostic subgroups for OS after recurrence, and appears to be a strong prognostic factor correlated to the pattern of recurrence. Funding Statement: The authors report no source of financial support for the research. Declaration of Interests: The authors report no conflict of interest. Ethics Approval Statement: The study was approved by the Ethics Committee of the National College of French Gynaecologists and Obstetricians (CNGOF) (CEROG 2016-GYN-0502).