Recurrence of Peptic Ulcer in Man as Affected by Treatment with an Enterogastrone Preparation

Abstract

Summary 1.Forty-six patients who received a course of enterogastrone injections (in most instances 3 or 6 times per week for one year) and whose subsequent course after stopping the treatment has been followed for as long as 5 years are reported upon. 2.During the year of treatment 41 per cent of the patients were symptom free and an additional 46 per cent had fewer recurrences. At the end of the second year (after discontinuing treatment) 40 per cent had fewer recurrences. 3.The average of the longest symptom free period in these 46 patients was 0.3 year during the 2 year period prior to therapy and 0.9 year after the therapy. The difference between 0.3 and 0.9 year is statistically significant. 4.Our results are sufficiently clear to cause us to conclude that there is probably an antiulcer substance in the enterogastrone preparation which tends to prevent recurrences in man. The purification of this factor is the subject of continuing research.