Abstract
ObjectiveThe aim of this study was to investigate recurrences and survival in endometrioid endometrial cancer (EC) in a complete population-based cohort. MethodsA regional population-based study including women with endometrioid EC, identified by the Swedish Quality Registry for Gynecological Cancer (SQRGC), where primary surgery was performed between 2010 and 2017. Patient characteristics and outcomes, including recurrences, were retrieved from the SQRGC and completed by records reviews. Overall (OS), net (NS) and disease-free survival (DFS) were calculated using the Kaplan-Meier method. The Fine and Gray proportional subdistribution hazards' regression model was used for risk factors for recurrence. ResultsThere were 1630 women included in the study, whereof 136 (8.3%) had a recurrence with a median time to recurrence of 22.5 months (range 3.2–59.3). One site of recurrence was diagnosed in 69.1%, while 27.2% being only vaginal. The total 5-year OS was 88.0%(95% CI:86.4–89.7) and the 5-year NS 98.6%(95% CI:96.5–100.7). If no recurrence occurred, the OS was 91.9%(95% CI:90.4–93.3) and NS 102.8%(95% CI:100.9–104.8). For only vaginal recurrence, 5-year OS was 77.0%(95% CI:64.0–92.6) compared to 36.1%(95% CI:27.5–47.3) for all other recurrences. The total 5-year DFS was 83.9%(95% CI:82.0–85.7). In the multivariable analysis, age, FIGO stage and primary treatment were found independent factors for recurrence with a HR of 1.29(95% CI:1.11–1.51;p = 0.001) for age, 2.78(95% CI:1.80–4.29;p < 0.001) for FIGO stage III and 1.84(95% CI:1.22–2.78;p 0.004) for adjuvant treatment. ConclusionThere is an overall low recurrence rate for endometrioid ECs with a minor portion being only vaginal, associated with a favorable survival in contrast to other recurrences with a poor prognosis. Age, FIGO stage III and adjuvant treatment were found independent prognostic factors for recurrence.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.