Recurrence and metastasis of lung cancer demonstrate decreased diffusion on diffusion-weighted magnetic resonance imaging.

Katsuo Usuda,Tsutomu Sakuma,Hisao Tonami,Yoshimichi Ueda,Makoto Tanaka,Yuichiro Machida,Munetaka Matoba,Motoyasu Sagawa,Sumiko Maeda,Masakatsu Ueno,Nozomu Motomo

doi:10.7314/apjcp.2014.15.16.6843

Abstract

Diffusion-weighted magnetic resonance imaging (DWI) is reported to be useful for detecting malignant lesions. The purpose of this study is to clarify characteristics of imaging, detection rate and sensitivity of DWI for recurrence or metastasis of lung cancer. A total of 36 lung cancer patients with recurrence or metastasis were enrolled in this study. While 16 patients underwent magnetic resonance imaging (MRI), computed tomography (CT) and positron emission tomography-computed tomography (PET-CT), 17 underwent MRI and CT, and 3 underwent MRI and PET-CT. Each recurrence or metastasis showed decreased diffusion, which was easily recognized in DWI. The detection rate for recurrence or metastasis was 100% (36/36) in DWI, 89% (17/19) in PET-CT and 82% (27/33) in CT. Detection rate of DWI was significantly higher than that of CT (p=0.0244) but not significantly higher than that of PET-CT (p=0.22). When the optimal cutoff value of the apparent diffusion coefficient value was set as 1.70?10-3 mm2/sec, the sensitivity of DWI for diagnosing recurrence or metastasis of lung cancer was 95.6%. DWI is useful for detection of recurrence and metastasis of lung cancer.

Highlights

Diffusion-weighted magnetic resonance imaging (DWI) exploits the random, translational motion, or so-called Brownian movement, of water molecules in biologic tissue (Le Bihan et al, 1988)
It was recognized by computed tomography (CT), positron emission tomography-computed tomography (PET-CT) and DWI
Detection of recurrence or metastasis of lung cancer is an important issue in the follow-up of the cancer treatment

Summary

Introduction

Diffusion-weighted magnetic resonance imaging (DWI) exploits the random, translational motion, or so-called Brownian movement, of water molecules in biologic tissue (Le Bihan et al, 1988). Diffusion-weighted magnetic resonance imaging (DWI) is reported to be useful for detecting malignant lesions. The purpose of this study is to clarify characteristics of imaging, detection rate and sensitivity of DWI for recurrence or metastasis of lung cancer. The detection rate for recurrence or metastasis was 100% (36/36) in DWI, 89% (17/19) in PET-CT and 82% (27/33) in CT. When the optimal cutoff value of the apparent diffusion coefficient value was set as 1.70×10-3 mm2/sec, the sensitivity of DWI for diagnosing recurrence or metastasis of lung cancer was 95.6%. Conclusions: DWI is useful for detection of recurrence and metastasis of lung cancer

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