Recurrence after successful catheter ablation for ventricular arrhythmia from the aortic root

Abstract

Objective: The mechanism underlying recurrence after successful ablation of ventricular arrhythmias (VAs) was unclear. Spectrum analysis can help to identify near-field activation. The purpose of this study was to quantify the changes of near-field activation in response to ablation at the VAs origin in the aortic root (AR-VAs) and to assess its relationship with late ablation outcome.Methods and results: Patients who underwent acutely successful ablation for AR-VAs were analysed. Ventricular electrograms acquired before and after ablation at VAs origin were subjected to spectrum analysis. The area under the curve of the high frequency component (HFC, 50–200 Hz) and the low frequency component (LFC, 0–50 Hz) was measured. The proportion of HFC to the frequency spectrum of 0–200 Hz was defined as the HFC ratio (HFCR). The reduction of HFC and HFCR in response to ablation was defined as HFC pre–post and HFCR pre–post, respectively. Documentation of VAs with the same morphology after an acute successful procedure was defined as recurrence. Fifty-six patients were analysed, and VAs recurred in 17 patients. HFCR pre–post, HFC pre–post, and HFC pre-ablation were significantly higher in patients without recurrence. And HFCR pre–post has the highest predictive value (area under the receiver-operating characteristic curve: 0.975). A HFCR pre–post of 1.0% differentiated two groups (sensitivity = 84.6%, specificity = 100%). Higher HFCR pre–post was correlated with shorter VAs termination time (correlation coefficient = –0.399, p = .009).Conclusions: HFCR pre–post can quantify the near-field activation change during ablation. Incomplete destruction to the VAs foci could underlie recurrence after successful ablation.