Abstract
BackgroundRecruitment and retention of participants in surgical trials is challenging. Knowledge of the most common and problematic issues will aid future trial design. This study aimed to identify trial staff perspectives on the main issues affecting participant recruitment and retention in UK surgical trials.MethodsAn online survey of UK surgical trial staff was performed. Respondents were asked whether or not they had experienced a range of recruitment and retention issues, and, if yes, how relatively problematic these were (no, mild, moderate or serious problem).ResultsThe survey was completed by 155 respondents including 60 trial managers, 53 research nurses, 20 trial methodologists and 19 chief investigators. The three most common recruitment issues were: patients preferring one treatment over another (81·5 per cent of respondents); clinicians' time constraints (78·1 per cent); and clinicians preferring one treatment over another (76·8 per cent). Seven recruitment issues were rated moderate or serious problems by a majority of respondents, the most problematic being a lack of eligible patients (60·3 per cent). The three most common retention issues were: participants forgetting to return questionnaires (81·4 per cent); participants found to be ineligible for the trial (74·3 per cent); and long follow‐up period (70·7 per cent). The most problematic retention issues, rated moderate or serious by the majority of respondents, were participants forgetting to return questionnaires (56·4 per cent) and insufficient research nurse time/funding (53·6 per cent).ConclusionThe survey identified a variety of common recruitment and retention issues, several of which were rated moderate or serious problems by the majority of participating UK surgical trial staff. Mitigation of these problems may help boost recruitment and retention in surgical trials.
Highlights
Surgical trials are experiencing a renaissance in the UK, thanks to investment in new infrastructure, training and methodological research; this has coincided with a doubling in the number of patients entering UK-based surgical randomized trials over a 5-year period[1]
The survey was completed by 155 UK surgical trial staff
Respondents included 60 trial managers/coordinators (38⋅7 per cent), 53 research nurses (34⋅2 per cent), 20 methodologists (12⋅9 per cent) with an interest in recruitment and/or retention, 19 chief investigators
Summary
Surgical trials are experiencing a renaissance in the UK, thanks to investment in new infrastructure, training and methodological research; this has coincided with a doubling in the number of patients entering UK-based surgical randomized trials over a 5-year period[1]. Seven recruitment issues were rated moderate or serious problems by a majority of respondents, the most problematic being a lack of eligible patients (60⋅3 per cent). The most problematic retention issues, rated moderate or serious by the majority of respondents, were participants forgetting to return questionnaires (56⋅4 per cent) and insufficient research nurse time/funding (53⋅6 per cent). Conclusion: The survey identified a variety of common recruitment and retention issues, several of which were rated moderate or serious problems by the majority of participating UK surgical trial staff. Mitigation of these problems may help boost recruitment and retention in surgical trials
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