Recovery therapy after photodynamic therapy of background and precancerous diseases of the vulva

Abstract

A comprehensive approach that includes the treatment of background and precancerous diseases of the vulva by photodynamic therapy and plasma therapy as rehabilitation therapy was developed. The method’s effectiveness was evaluated. The study is also aimed at evaluating the effectiveness of plasma therapy after treatment of background and precancerous diseases of the vulva by photodynamic therapy. The work is based on the study results of 60 patients aged 32 to 70 years old, mean age was (53.3+3.6) years, with a morphologically verified diagnosis of vulvar intraepithelial neoplasia, mixed vulvar dystrophy (Lichen sclerosus et atrophicus, squamous cell hyperplasia), which were divided into two groups. Patients of both groups underwent photodynamic therapy using an intravenous photosensitizer «Fotolon®» (RUE «Belmedpreparaty», Republic of Belarus), which is a complex of chlorine ебс trisodium salt with low molecular weight polyvinylpyrrolidone. The session of photodynamic therapy was performed 3^1 hours after the end of the FS infusion using a universal laser coagulator «Likar-Hirurg (Surgeon)» («Photonica Plus», Ukraine, A-660 nm). Plasma therapy was performed for patients of group 2 after photodynamic therapy. It has been established that the use of photodynamic therapy and plasma therapy increases the effect of treatment of background and precancerous diseases of the vulva, accelerates the period of damaged tissues regeneration and rehabilitation of patients twice and prolongs the recurrence-free period of the disease. Keywords: photodynamic therapy, plasma therapy, precancerous diseases of the vulva.