Recovery outcome of Thiopentone vs. Propofol as anaesthetic agent in pediatric patients of 2-10 years age group undergoing magnetic resonance imaging (MRI)

Abstract

Background: Children between 2-10 years age group who undergo magnetic resonance imaging (MRI) requires sedation/ general anaesthesia for good quality images, as immobility is very essential. Providing sedation/GA in an MRI suite is quite different than in operation theatre. This study is undertaken to compare two drugs Propofol and Thiopentone as anaesthetic agents to provide sedation and immobilization during MRI and to compare their recovery time and recovery characteristics in children between age 2-10 years undergoing MRI. Aims and objectives: To compare the recovery outcome of Thiopentone and Propofol as an anaesthetic agent in children undergoing MRI of age 2-10 yrs. Objectives: to assess the recovery by Glasgow coma scale (GCS) immediately after the procedure, at the end of 15mins, 30mins and 1hour. Methodology: This Quasi Experimental study was conducted on 40 children who were undergoing elective MRI for various reasons, were divided into two groups, using sealed envelope method. Group T (Thiopentone): n=20 Group P (Propofol): n=20, A detailed preanaesthetic evaluation was done. Instructed NPO guidelines were followed and premedication with Triclofos 50mg/kg and Atropine 0.02mg/kg was given 60 minutes before the scheduled time. Patients in the T group were induced with inj. Thiopentone 4mg/kg, and maintained with 0.5-1mg/kg/min. patients in group P were induced with inj. Propofol 1mg/kg and maintained with 100-150mcg/kg/min. Study begins at the end of the procedure, where parameters like response to oral commands, and GCS assesment immediately, at 15min, 30 min and at the end of 1 hour are noted. Results: GCS assessment in Propofol group was better statistically as the p value was 0.002, 0.013, 0.00 and 0.00 at various time interval. Conclusion: The Propofol group had faster and complete recovery, when compared to Thiopentone group.