Abstract
The hamster (HT- 1 line) and the mouse (D- 243 line) cultures are murine sarcoma virus (MSV) transformed cells which do not produce infectious virus. Nuclear DNA was isolated from these cells. This DNA was used to treat normal mouse embryo cells ( 3T 3 line) and Rauscher leukaemia virus (RLV) infected 3T 3 cells. Both cell cultures became transformed, but only the RLV infected 3T 3 cells released infectious MSV. The nuclear DNA lost its biological activity following treatment with D Nase. These experiments indicate that vertical transmission of mammalian C-type RNA virus is carried by the nuclear DNA of the viral transformed cells.
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