Abstract
A method based on ion exchange chromatography is presented for the recovery of 201Tl and its precursor 201Pb from proton bombarded natural thallium cyclotron targets. After bombardment the target is dissolved in diluted nitric acid. Water, hydrazine and ammonium acetate are added to the solution and the lead radioisotopes separated from the thallium by cation exchange chromatography on a Bio-Rex 70 column. The sorbed lead radioisotopes are eluted with dilute nitric acid and the separation repeated on a second Bio-Rex 70 column. After elution of the remaining thallium the column is left for 32 hours and the 201Tl formed by decay of 201Pb is eluted with an ammonium acetate solution. The 201Tl eluate is acidified with a HNO3-HBr-Br2 mixture and the resulting solution is passed through an AG MP-1 anion exchanger column to remove any remaining lead isotopes. The 201Tl is eluted with a hydrazine solution, the eluate evaporated to dryness and the 201Tl finally dissolved in an appropiate solution to produce a 201TlCl solution suitable for medical use. A high quality 201Tl product is obtained containing ≤0.1 μg of Tl/mCi (37 MBq) 201Tl. The radionuclidic impurities are less than the maximum values specified by the US Pharmacopoeia and the British Pharmacopoeia.
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