Recovery characteristics of auditory nerve fibres in the normal and noise-damaged guinea pig cochlea

Abstract

Spontaneous activity was analysed in auditory-nerve fibres innervating normal and noise-damaged cochleas. Spike occurrences were conceived as point processes. Joint interval distributions and serial correlation coefficients reveal a weak history effect for succeeding intervals. The point process is regarded as a renewal and the recovery function, being proportional to the hazard function, is determined from the interval probability density function. In 29 out of 60 fibres the latter shows peculiarities which result in a deviation from a monotonically increasing recovery function. For three fibres of low characteristic frequency the interval probability function shows an oscillatory pattern and for 26 fibres this function exhibits an early, sharp peak around 1.1 ms irrespective of characteristic frequency, spontaneous rate, or cochlear damage. The recovery function is not different between fibres with normal and those with abnormally high thresholds and exhibits an exponential recovery with one time constant of average value 1.6 ms. Bursting activity is found in only one fibre from the abnormally high threshold group.