Reconstruction with In-Line Digital Holography Quantitative Phase Imaging for Tissue-Mimicking Phantom Samples

Abstract

Optical imaging has attracted recent attention as a non-invasive medical imaging method in biomedical and clinical applications. In optical imaging, a light beam is transmitted through an under-test tissue by using an optical source. The beams which are gone through the tissue and/or reflected from the tissue surfaces are received by an array sensor. Based on the light intensity of these received beams on the sensor, sub-tissue maps are generated to scan large tissue areas so that any further biopsy is not required. Although the large tissue areas in pathological images can be scanned by using various methods, nonlinear deformations occur. To overcome this problem, the reconstruction process is frequently used. In this study, we propose an application of biomedical imaging based on performing the reconstruction of a phantom image via an in-line digital holography technique. Hence, many different sub-tissues can be imaged at the same time without the storage problem of the reconstructed image. To neglect the biopsy process required in medical imaging, the phantom image is obtained by using a linear array transducer for this study. We present the performance evaluation of the simulation results for the proposed technique by calculating the error metrics such as mean squared error (MSE), mean absolute error (MAE), and peak signal-to-noise ratio (PSNR). The obtained results reveal that the reconstructed images are well-matched to the original images, which are desired to be displayed by the holography technique.