Reconstruction of the Canine Mandible Using a Custom Made Bioabsorbable u-HA/PLLA Mesh Tray With PCBM and PRP

Abstract

StatementMandibular reconstruction is one of the most challenging fields in oral and maxillofacial surgery. Particulate cancellous bone and marrow (PCBM) combined with platelet rich plasma (PRP) is highly effective for mandibular reconstruction by minimally invasive surgery, but it is frequently difficult to make it titanium mesh tray fit the defect, and achieve a suitable contour. We have successfully developed a bioresorbable mesh tray system which is customized using a rapid prototyping method to replace the metal tray. We report the results of mandibular reconstruction using PCBM, PRP, and the bioresorbable mesh tray system in dog.Materials and MethodsAnimal: Four 2-year-old beagles.Tray: u-HA/PLLA composite (OSTEOTRANSTM: Takiron Co Ltd)Customized methodA stereolithograph is made using data from a CT scan of the canine mandible. A tray was then formed according to the surface of the mandible model.SurgeryFirst, PRP was made from venous blood. Then, after inducing intravenous general anesthesia, iliac bone was harvested, and bone defects were made bilaterally on the lower border of the mandible in the premolar area. A bioresorbable tray was adopted to the defect on the right side, and the titanium tray to that on the left. PCBM and PRP were mixed and compressed into the defect.Method of Data AnalysisX-ray and histological evaluation were done at 1 and 3 months.ResultsThe bone formation observed in the bioabsorbable tray was as good as in the titanium tray. Bone conduction to the bioabsorbable tray was recognized histologically.ConclusionThis bioresorbable tray system not only solves the problems of the conventional tray, but also holds hope as an external scaffold for tissue engineering. StatementMandibular reconstruction is one of the most challenging fields in oral and maxillofacial surgery. Particulate cancellous bone and marrow (PCBM) combined with platelet rich plasma (PRP) is highly effective for mandibular reconstruction by minimally invasive surgery, but it is frequently difficult to make it titanium mesh tray fit the defect, and achieve a suitable contour. We have successfully developed a bioresorbable mesh tray system which is customized using a rapid prototyping method to replace the metal tray. We report the results of mandibular reconstruction using PCBM, PRP, and the bioresorbable mesh tray system in dog. Mandibular reconstruction is one of the most challenging fields in oral and maxillofacial surgery. Particulate cancellous bone and marrow (PCBM) combined with platelet rich plasma (PRP) is highly effective for mandibular reconstruction by minimally invasive surgery, but it is frequently difficult to make it titanium mesh tray fit the defect, and achieve a suitable contour. We have successfully developed a bioresorbable mesh tray system which is customized using a rapid prototyping method to replace the metal tray. We report the results of mandibular reconstruction using PCBM, PRP, and the bioresorbable mesh tray system in dog. Materials and MethodsAnimal: Four 2-year-old beagles.Tray: u-HA/PLLA composite (OSTEOTRANSTM: Takiron Co Ltd) Animal: Four 2-year-old beagles. Tray: u-HA/PLLA composite (OSTEOTRANSTM: Takiron Co Ltd) Customized methodA stereolithograph is made using data from a CT scan of the canine mandible. A tray was then formed according to the surface of the mandible model. A stereolithograph is made using data from a CT scan of the canine mandible. A tray was then formed according to the surface of the mandible model. SurgeryFirst, PRP was made from venous blood. Then, after inducing intravenous general anesthesia, iliac bone was harvested, and bone defects were made bilaterally on the lower border of the mandible in the premolar area. A bioresorbable tray was adopted to the defect on the right side, and the titanium tray to that on the left. PCBM and PRP were mixed and compressed into the defect. First, PRP was made from venous blood. Then, after inducing intravenous general anesthesia, iliac bone was harvested, and bone defects were made bilaterally on the lower border of the mandible in the premolar area. A bioresorbable tray was adopted to the defect on the right side, and the titanium tray to that on the left. PCBM and PRP were mixed and compressed into the defect. Method of Data AnalysisX-ray and histological evaluation were done at 1 and 3 months. X-ray and histological evaluation were done at 1 and 3 months. ResultsThe bone formation observed in the bioabsorbable tray was as good as in the titanium tray. Bone conduction to the bioabsorbable tray was recognized histologically. The bone formation observed in the bioabsorbable tray was as good as in the titanium tray. Bone conduction to the bioabsorbable tray was recognized histologically. ConclusionThis bioresorbable tray system not only solves the problems of the conventional tray, but also holds hope as an external scaffold for tissue engineering. This bioresorbable tray system not only solves the problems of the conventional tray, but also holds hope as an external scaffold for tissue engineering.