Abstract
BackgroundReconstruction of large-size abdominal wall defect (AWDs) is a huge challenge faced in current surgical practice. In this study, we aimed to evaluate the effectiveness and safety of biodegradable poly-p-dioxanone (PDO) mesh for reconstructing large-size AWDs in an experimental canine model.MethodsEighteen experimental canines were randomly and equally divided into three groups, namely, a PDO group, a Marlex group and a control group (n = 6 each). Following the creation of a 6 cm × 5.5 cm AWD, PDO mesh and Marlex mesh were used to reconstruct the defect in the PDO and Marlex groups, respectively. The defect was closed using relaxation sutures alone in the control group. Animals were killed 24 weeks after surgery, and reconstruction outcomes were evaluated using radiography, histology and biomechanical testing.ResultsAll animals except those in the control group survived the experiment. The PDO group showed no wound dehiscence, herniation or infection, whereas the animals in the Marlex group exhibited marked foreign body reactions. The PDO group had less intraabdominal adhesion than the Marlex group. As shown by radiography, histology and biomechanical testing, PDO mesh exhibited complete degradation and favorable biochemical strength at 24 weeks postsurgery.ConclusionsPDO mesh implantation is an effective, safe treatment modality for reconstructing large-size AWDs.
Highlights
Reconstruction of large-size abdominal wall defect (AWDs) is a huge challenge faced in current surgical practice
Marlex mesh remained radiopaque throughout the 12 weeks after surgery (Figure 4B)
This radiopacity had mostly disappeared at 24 weeks, indicating that the PDO mesh had nearly completely degraded (Figure 4C)
Summary
Reconstruction of large-size abdominal wall defect (AWDs) is a huge challenge faced in current surgical practice. We aimed to evaluate the effectiveness and safety of biodegradable poly-p-dioxanone (PDO) mesh for reconstructing large-size AWDs in an experimental canine model. Small-size AWDs can be closed using the residual abdominal wall soft tissues; reconstruction of large-size AWDs normally require the use of prostheses and remain a huge challenge in current general surgical practice. It is essential to optimize the choice of mesh materials for successful AWD reconstruction. Composite meshes with protease-treated bovine skin collagen (atelocollagen) are currently available, but increased infection susceptibility and long-term coating failure have been reported [17,18]. Rapid degradation of biodegradable materials compromises the mechanical stability and limits the use of these materials in large-size AWD reconstruction
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
