Abstract
Introduction: Loss of tissue and dysfunction of body organs due to injuries and diseases have caused serious health problems despite the vast advances in Medicien. Bone repair through tissue engineering is one of the most important areas of attention for specialists in a wide range of de- partments, including orthopedics and maxillofacial surgeries.
 Materials and Methods: This case-series describes efficient clinical applications of adi- pose-derived stem cells (AdSCs) in combination with conventional guided bone regeneration as protected healing space for reconstruction of large alveolar defects after hemi-mandibulectomy.
 Results: As the result, this approach represented a considerable amount of three-dimensional bone formation in presented cases. Regenerating this amount of resected bone tissue rehabilitates the patients and gives clinicians a sufficient amount of bone and opportunity to insert dental implants to retrieve patients’ function and aesthetic.
 Conclusion: The application of AdSCs can be considered as an efficient treatment for bone regeneration in large alveolar bone defects.
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