Abstract
This talk introduces a symposium focusing on current efforts to dissect nicotinic and non-nicotinic mechanisms of synaptic transmission in autonomic ganglia and their integrative consequences in health and disease. We begin with a general theory of ganglionic integration. This framework incorporates basic features of synaptic divergence and convergence that operate in most paravertebral sympathetic ganglia. The goal is to reconstruct the integrative properties of ganglia from the bottom up beginning with nicotinic synapses and using information from the literature describing natural patterns of activity observed in experimental animals and in awake human subjects.
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