Reconsidering vitamin D optimal values based on parathyroid hormone levels in a North Algerian cohort: stratification by gender and season.

Abstract

There is no consensus defining the vitamin D optimal values. The aim of this study is to establish vitamin D optimal values in the Northern Algerian population, based on its skeletal effects as represented by the inverse relationship between 25-hydroxy vitamin D (25(OH) D) and parathyroid hormone (PTH). 451 healthy volunteers of both genders, aged 19 to 79years, were enrolled in a cross-sectional study conducted at the medical analysis laboratory of the University Hospital of Blida, Algeria. 25(OH) D was assessed by a sequential competitive immuno-fluoroassay technique. Determination of vitamin D optimal values was performed based on the kinetic relationship between 25(OH) D and PTH, as explored by inverse nonlinear regression on a spline plots curve. The optimal value represents the 25(OH) D level at which PTH ceases to increase and reaches a virtual plateau. In men and women, respectively, the 25 (OH) D thresholds are estimated at 25.0ng/ml and 30ng/ml, above this value, PTH stabilizes in a virtual plateau, estimated at 22.3pg/ml and 26.8pg/ml. In warm and cold seasons, respectively, the 25 (OH) D cut-offs are estimated at 30.0ng/ml and 25.0ng/ml, from these values, the PTH stabilizes in a virtual plateau, estimated at 21.5pg/ml and 27.7pg/ml. In this study, the optimal values of 25(OH) D were defined for the first time in a North Algerian adult population. The optimal value is 25.0ng/ml in men and 30.0ng/ml in women.