Abstract
In 1977 experts gathered in Turin (Italy) at a meeting held under the auspices of the World Health Organization (WHO) to discuss the standardization of reporting the results of cancer treatment. Since then, tumor-related outcome criteria (disease progression, complete response, partial response, etc.) have become a widely applied yardstick in clinical trials. In clinical practice, surgery, chemotherapy and radiotherapy have become increasingly effective in controlling disease. Yet less is known about the patient’s functioning and health-related quality of life after treatment, when improved survival may come at the cost of increased long-term ‘‘toxicity’’. In neuro-oncology, the concept of patient-related outcome, comprising patient-reported outcome, objective neurological examination and performance scales, has developed at an uneven pace. Extensive study into patientreported outcome has resulted in validated questionnaires, while objective neurological examination and (non-specific) performance scales date back to decades ago. Added to these is cognitive testing, providing reliable instruments
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