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Abstract
Reconsidering Early HIV Treatment and Supervised Treatment Interruptions
Highlights
The devastating effects of HIV infection worldwide are reason enough for AIDS researchers to grasp at thin rays of hope
Consistent with this hypothesis was the prior finding that early antiretroviral therapy led to induction of HIV-specific proliferative responses similar to those that had been observed in patients with long-term, non-progressing HIV [2]
This led Rosenberg and colleagues to ask whether HIV-specific proliferative responses were a necessary and sufficient cause of long-term nonprogression or just an immunologic consequence of controlled virus replication
Summary
The devastating effects of HIV infection worldwide are reason enough for AIDS researchers to grasp at thin rays of hope. This, in turn, according to the hypothesis, leads to control of viral replication by a healed and appropriately stimulated immune response to the patient’s HIV infection Consistent with this hypothesis was the prior finding that early antiretroviral therapy led to induction of HIV-specific proliferative responses similar to those that had been observed in patients with long-term, non-progressing HIV [2]. This led Rosenberg and colleagues to ask whether HIV-specific proliferative responses were a necessary and sufficient cause of long-term nonprogression or just an immunologic consequence of controlled virus replication.
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