Recommendations on oral lichen by GEMUB !

Jean-Christophe Fricain

doi:10.1051/mbcb/2019036

Abstract

Recommendations on oral lichen by GEMUB !

Highlights

Complex by: – the variety of intraoral clinical forms which includes numerous elementary lesions (keratotic papule, keratotic network, keratotic plaque, erythema, erosion, ulceration, bubble, macula), – multiple locations: skin or the integuments (hair, nails), mucous membranes (genital, anal, esophagus, conjunctiva), – the evolution towards other pathologies (leucoplakia like lesion, verrucous proliferative leukoplakia, verrucous carcinoma, squamous cell carcinoma), – the overlap with other bullous diseases (pemphigoid lichen planus, chronic ulcerative stomatitis), – the existence of lichenoid lesions more or less clinically or histologically similar to idiopathic oral lichen planus, – the existence of lichenoid lesions induced by a systemic disease (graft versus host disease, hepatitis c, good syndrome, APECED ...), – the existence of lichenoid lesions induced by an old drug (e.g. chloroquine) or more modern (e.g. check point inhibitor)
Complex by: – the variety of intraoral clinical forms which includes numerous elementary lesions, – multiple locations: skin or the integuments, mucous membranes, – the evolution towards other pathologies, – the overlap with other bullous diseases, – the existence of lichenoid lesions more or less clinically or histologically similar to idiopathic oral lichen planus, – the existence of lichenoid lesions induced by a systemic disease, – the existence of lichenoid lesions induced by an old drug or more modern
The first work of recommendations of the study group of the oral mucosa (GEMUB) has set its sights on this pathology to clarify the elements of the diagnostic workup

Summary

Introduction

Complex by: – the variety of intraoral clinical forms which includes numerous elementary lesions (keratotic papule, keratotic network, keratotic plaque, erythema, erosion, ulceration, bubble, macula), – multiple locations: skin or the integuments (hair, nails), mucous membranes (genital, anal, esophagus, conjunctiva), – the evolution towards other pathologies (leucoplakia like lesion, verrucous proliferative leukoplakia, verrucous carcinoma, squamous cell carcinoma), – the overlap with other bullous diseases (pemphigoid lichen planus, chronic ulcerative stomatitis), – the existence of lichenoid lesions more or less clinically or histologically similar to idiopathic oral lichen planus, – the existence of lichenoid lesions induced by a systemic disease (graft versus host disease, hepatitis c, good syndrome, APECED ...), – the existence of lichenoid lesions induced by an old drug (e.g. chloroquine) or more modern (e.g. check point inhibitor). The multiplicity of the forms of oral lichen helps to create a “medical blur” that makes the assessment and treatment of oral lichen difficult. The first work of recommendations of the study group of the oral mucosa (GEMUB) has set its sights on this pathology to clarify the elements of the diagnostic workup.

Results

Conclusion