Abstract
Recommendations for the management of indeterminate HIV PCR results within South Africa’s early infant diagnosis programme
Highlights
Infant diagnosis (EID) of HIV using highly sensitive polymerase chain reaction (PCR) methods and rapid linkage for the treatment of those who test positive is considered the gold standard of paediatric HIV care
One HIV PCR-positive result in association with an HIV VL that is detectable on a separate specimen is diagnostic of HIV
An indeterminate HIV PCR result means that the test is inconclusive
Summary
Infant diagnosis (EID) of HIV using highly sensitive polymerase chain reaction (PCR) methods and rapid linkage for the treatment of those who test positive is considered the gold standard of paediatric HIV care. The laboratory diagnosis of HIV in infants less than 18 months of age requires two HIV PCR-positive results, each on a separate specimen, as per South Africa’s National Consolidated Guidelines of 01 June 2015. One HIV PCR-positive result in association with an HIV VL that is detectable on a separate specimen is diagnostic of HIV.
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