Abstract
In this study we report the first instance of recombination between kappa chain genetic markers in the mouse. The recombination frequency, 0.45% (95% limits, 0.12-1.61), is similar to that previously found for recombination between the kappa chain locus and the Lyt-2,3 locus (0.3%, 95% limits, 0.05-1.6), but is relatively low in comparison with that found at the heavy chain locus (0.41-5.4%). Lyt-2,3-typing of the recombinants permits a partial ordering of the kappa chain and Lyt-2,3 loci as (Lyt-2,3, Igk-Ef1) - Igk-Ef2. Light chains controlled by the two kappa markers include the Vk-(ser) subgroup (controlled by Igk-Ef1) and Vk-1 (controlled by Igk-Ef2). One of the recombinants has been recovered in a homozygous state ("NAK") and should be suitable for Vk gene mapping studies.
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