Abstract
The role of phylogeny in guiding comparative studies is rapidly growing in the post genomic era. Most phylogeny reconstruction methods though, assume a single tree underlying a given alignment of sequences. However, when events such as recombination occur, different regions in the alignment may have different underlying trees. In this paper, we demonstrate via simulations, the effect of recombination on the accuracy of phylogeny reconstruction methods. Our results, coupled with the significance of recombination as an evolutionary mechanism, make it imperative to devise efficient and accurate methods for detecting recombination in sequence datasets. Hence, we introduce a simple, yet effective, method for detecting recombination in a given alignment, based on incongruence among phylogenetic trees in different regions of the alignment. We have studied the performance of our method on synthetic and biological datasets, and obtained good results.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Bioinformatics Research and Applications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
