Abstract
The inhibitory mechanism of gastric acid secretion induced by human recombinant interleukin-1β was investigated in bilaterally vagotomized, urethane-anesthetized rats. Intracerebroventricular administration of interleukin-1β (10, 50 and 100 ng/animal) dose dependently inhibited the gastric acid secretion induced by electrical stimulation of the vagus nerve at 3 Hz. Inhibition of gastric acid secretion induced by interleukin-1β (50 ng/animal) was abolished both by splanchnectomy and by phentolamine (5 mg/kg i.m.). Greater splanchnic nerves ramify into the adrenal branch and gastric sympathetic preganglionic branch. The interleukin-1β (50 ng/animal)-induced inhibition was also abolished by intracerebroventricular pretreatment with indomethacin (500 μg/animal), while pretreatment with the same dose of this reagent by the intraperitoneal route was without effect. These results suggest that centrally administered interleukin-1β induces a prostaglandin-mediated central excitation of the sympatho-adrenomedullary system, and the resultant activation of gastric α-adrenoceptors inhibits the vagally stimulated gastric acid secretion in rats.
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