Abstract
Background: Beside of pathophysiological interest, estimation of intrathecal synthesis (IS) of paraneoplastic antineuronal antibodies may increase the diagnostic sensitivity in rare cases of patients with clinically suggestive paraneoplastic neurological syndromes (PNS) and negative or uncertain results in serum. Detection of antigen-specific oligoclonal bands (OCB) in CSF seems to be the most sensitive marker of IS. However, this technique is not suitable for routine laboratory testing.
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