Abstract
Objective: Human preimplantation embryos are routinely cultured in the presence of a macromolecule, typically in the form of patient’s serum or human serum albumin (HSA). Although embryo development can be achieved in the absence of a macromolecule, both embryo development and handling are improved by the presence of a macromolecule. Exposure of an embryo to serum is not an appropriate procedure, whereas the use of HSA is associated with both biological variation and the possibility of disease transmission. Albumin is the most abundant macromolecule in the oviduct, while significant levels of hyaluronan (HA) are present in the uterus. We have therefore investigated the efficacy of recombinant HSA (rec-HSA) and HA (rec-HA) in a mouse embryo culture system.
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