Abstract
Objective To observe the effects of recombinant human endostatin, Endostar, on tumor lymphangiogenesis and lymph node metastasis in a mouse xenograft model of colon cancer. Methods Human colon cancer SW620 cells were implanted subcutaneously into the hind flank of the male nu/nu mice to estab-lish a xenograft model. The control group was treated with normal saline, and the Endostar group was treated with Endostar by subcutaneous injection every other day. Results (1) The rate of lymph node metastasis was 10% (1/10) in the Endostar group, and 80% (8/10) in the control group (P <0.01 ) ; (2) The den-sity of lymphatic vessels in the Endostar group was decreased significantly as compared with the control group (7.17 ± 0. 75 vs. 14.83 ± 0.98 per field, P < 0.05 ) ; (3) Endostar inhibited the expression of vascular endo-thehal cell growth factor (VEGF)-C and VEGF-D proteins in tumor tissues and SW620 cells. Conclusion Recombinant human endostatin suppressed lymphangiogenesis and lymph node metastasis by inhibiting the ex-pression of VEGF-C and VEGF-D in a mouse xenograft model of colon cancer. Key words: Endostatin; Colorectal carcinoma; Lymphatic vessel; Metastasis
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