Abstract
Bone morphogenetic proteins (BMPs), belonging to the transforming growth factor-β superfamily, regulate many cellular activities including cell migration, differentiation, adhesion, proliferation and apoptosis. Use of recombinant human bone morphogenic protein?2 (rhBMP?2) in oral and maxillofacial surgery has seen a tremendous increase. Due to its role in many cellular pathways, the influence of this protein on carcinogenesis in different organs has been intensively studied over the past decade. BMPs also have been detected to have a role in the development and progression of many tumors, particularly disease-specific bone metastasis. In oral squamous cell carcinoma - the tumor type accounting for more than 90% of head and neck malignancies- aberrations of both BMP expression and associated signaling pathways have a certain relation with the development and progression of the disease by regulating a range of biological functions in the altered cells. In the current review, we discuss the influence of BMPs -especially rhBMP-2- in the development and progression of oral squamous cell carcinoma.
Highlights
We discuss the influence of Bone morphogenetic proteins (BMPs) -especially recombinant human bone morphogenetic protein-2 (rhBMP-2)- in the development and progression of oral squamous cell carcinoma
Bone morphogenetic proteins (BMPs) compose a family of growth factors known as cytokines and as metabologens (Reddi and Reddi, 2009), they belong to the family of TGF-β (Nana et al, 2015), which induces bone formation, regeneration and participates in many important steps during early embryonic development and homeostasis of diverse tissues and organs through regulating cellular differentiation(Kobayashi et al, 2005), proliferation (Chu et al, 2014; Peng et al, 2015), apoptosis (Peterkova et al, 1998; Kawamura et al, 2002; Hallahan et al, 2003) and motility (Perez et al, 2011; Kim et al, 2015)
The present review summarizes the current knowledge on the roles played by BMPs -especially rhBMP2- in oral squamous cell carcinoma
Summary
Bone morphogenetic proteins (BMPs) compose a family of growth factors known as cytokines and as metabologens (Reddi and Reddi, 2009) , they belong to the family of TGF-β (Nana et al, 2015), which induces bone formation , regeneration and participates in many important steps during early embryonic development and homeostasis of diverse tissues and organs through regulating cellular differentiation(Kobayashi et al, 2005), proliferation (Chu et al, 2014; Peng et al, 2015), apoptosis (Peterkova et al, 1998; Kawamura et al, 2002; Hallahan et al, 2003) and motility (Perez et al, 2011; Kim et al, 2015). BMP2 plays complicated roles, including the promotion of cell survival, regulation of cell proliferation, functional differentiation, cell motility, self-renewal and apoptosis of embryonic stem cells (Kang et al, 2009). BMP signals are transmitted from BMP receptor complexes exclusively localized at the basolateral surface of the cell membrane. Basolateral motivation with BMP increases the expression of components of tight junctions and increases the trans-epithelial resistance (TER) (Saitoh et al, 2013)
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