Abstract
Viral vectors based on recombinant adeno-associated virus (rAAV) have gained increasing interest over the last 20 years as a promising and safe gene-delivery vehicle for gene therapy. rAAV vectors posess many favorable characteristics, including an excellent safety profile, no pathogenicity, a wide host range comprising proliferating and nondividing cell types, the ability to deliver genes in vivo and in vitro, the competence to establish long-term transgene expression even in the absence of integration, and the relatively low immunogenicity. Although not used widely in dermatology, this review focuses on recent applications of rAAV vectors within the field of cutaneous gene therapy covering aspects of ex vivo gene transfer into keratinocytes, direct in vivo application to the skin, potential indications, such as wound healing and genodermatoses, as well as the basics of rAAV vectorology.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
