Abstract
Trauma is the leading cause of death in young people, and the leading cause of lost years of life in industrialized countries. 1 Considerable improvement in the care of trauma patients has been accomplished by organization of pre-hospital care, development of regionalized trauma systems, and improvement in the assessment of trauma patients by modern imaging techniques. Nevertheless, hemorrhage remains the first cause of death in trauma patients. Blood transfusion is associated with late complications and has been demonstrated to be an independent risk factor for development of infections 2 and multiple organ failure (MOF). 3 Moreover, coagulopathy remains a major contributing factor to bleedingrelated mortality, even after achieving surgical or radiological control of the hemorrhage in these patients. The association of coagulopathy, metabolic acidosis, and hypothermia has been described as the “lethal triad.” 4
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