Abstract
The prosomeric model was postulated jointly by L. Puelles and J. L. R. Rubenstein in 1993 and has been developed since by means of minor changes and a major update in 2012. This article explains the progressive academic and scientific antecedents leading LP to this collaboration and its subsequent developments. Other antecedents due to earlier neuroembryologists that also proposed neuromeric brain models since the late 19th century, as well as those who defended the alternative columnar model, are presented and explained. The circumstances that apparently caused the differential success of the neuromeric models in the recent neurobiological field are also explored.
Highlights
The present special number of BBEV titled ‘Beyond the prosomeric brain model’ offers me the opportunity to present some notes explaining how I came to be involved in the birth of this model
The tectal neuronal migration and differentiation data we described were later largely corroborated in subsequent studies using more modern techniques, notably by the American Sanes and his colleagues (Gray et al, 1988, 1990; Galileo et al, 1990; Gray and Sanes, 1991, 1992; Leber and Sanes, 1995)
I had checked in Badajoz whether the three tectal neuron prototypes were generally present in other parts of the brain. They were not, as was already suggested by existing Cajal data on the spinal cord, retina, and cerebellum, substantiating the conclusion that the brain wall was apparently divided into multiple areal progenitor units with differential histogenetic patterns and characteristic cell types
Summary
The prosomeric model was postulated jointly by L. Rubenstein in 1993 and has been developed since by means of minor changes and a major update in 2012. This article explains the progressive academic and scientific antecedents leading LP to this collaboration and its subsequent developments. Other antecedents due to earlier neuroembryologists that proposed neuromeric brain models since the late 19th century, as well as those who defended the alternative columnar model, are presented and explained. The circumstances that apparently caused the differential success of the neuromeric models in the recent neurobiological field are explored. Reviewed by: Marco Onorati, University of Pisa, Italy Andre Goffinet, Catholic University of Louvain, Belgium
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