Abstract
During the past decade, remarkable progress has been achieved for the open and endovascular management of abdominal aortic aneurysms (AAAs). However, the pathogenesis underlying the development of AAAs remains largely unknown, and as such, pharmacologic therapeutic options to prevent or to slow the growth of AAAs are lacking. A pathologic hallmark of AAA development is CD4+ T-cell inflammation. Regulatory T cells (Tregs), which can be identified with markers CD4+ and CD25+ and selective expression of Foxp3, serve as an important component of the immune system responsible for the maintenance of immunologic homeostasis and prevention of excessive inflammation.
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