Abstract
Putting the four DNA nucleosides in the middle of gold [111] nanoelectrodes with base planes parallel to the electrode surface layer, we study the transverse electronic transport properties of four nucleosides along the direction of electrodes. First, the optimal distance of the electrodes is released. The results show that the optimal electrode distance to study transverse electronic transport characteristics of DNA nucleosides is about 0.68 nm. Second, we theoretically calculate the conductance and current of the four nucleosides via perpendicular direction of base planes in the bias range of [−2, 2] V by exploiting the first principle theory. According to the calculated results, we propose three methods to recognize the nucleoside type in practice application.
Highlights
A rapid and cost-effective DNA sequencing technique would trigger the revolution of genome-based medical practice and would lead to a new phase of pharmaceuticals [1,2]
Since the electronic transport is sensitive to the molecule existing in the interelectrode gap, nucleotide recognition is possible and DNA sequencing is realizable in this way [5,6,7]
Very few studies have looked into transverse charge transport properties of the four nucleosides in DNA along the perpendicular direction of base planes
Summary
A rapid and cost-effective DNA sequencing technique would trigger the revolution of genome-based medical practice and would lead to a new phase of pharmaceuticals [1,2]. It is a promising method to use transverse electronic transport properties across a single-stranded DNA molecule to detect the four nucleobases: adenine (A), cytosine (C), guanine (G), and thymine (T) [3,4]. Since the electronic transport is sensitive to the molecule existing in the interelectrode gap, nucleotide recognition is possible and DNA sequencing is realizable in this way [5,6,7]. Very few studies have looked into transverse charge transport properties of the four nucleosides in DNA along the perpendicular direction of base planes. The four nucleosides, deoxyadenosine (A0), deoxycytidine (C0), deoxyguanosine (G0), and deoxythymidine (T0), are the basic units constructing DNA
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