Abstract
Parietal epithelial cells comprise a heterogeneous cell population lining Bowman's capsule. The study by Kuppe etal. focused on the peritubular region of Bowman's capsule and explored the cell biology of 2 poorly characterized subtypes-the intermediate and the cuboidal parietal epithelial cells. The early and exuberant proliferative response of these subgroups in murine focal segmental glomerulosclerosis (FSGS) and human glomerular tip lesions identified a novel hot spot for glomerular lesion formation.
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