Abstract
Recognition of infected cells has previously only been characterized for the major histocompatability complex (MHC)-class I binding, negative regulatory receptors of natural killer (NK) cells. With these receptors, a reduction in MHC class I at the cell surface releases inhibition of NK cell function and allows killing of infected cells. Recently Mandelboim et al. 1 Mandelboim O. et al. Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells. Nature. 2001; 409: 1055-1060 Crossref PubMed Scopus (750) Google Scholar demonstrated specific recognition of certain viral haemagglutinins by NKp46, one of the activating receptors of NK cells. Recognition involves a sialic acid on a carbohydrate group on NKp46 and is required for lysis of infected cells. However, other cellular receptors might also be involved.
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