Abstract
Recognition of infected cells has previously only been characterized for the major histocompatability complex (MHC)-class I binding, negative regulatory receptors of natural killer (NK) cells. With these receptors, a reduction in MHC class I at the cell surface releases inhibition of NK cell function and allows killing of infected cells. Recently Mandelboim et al. 1 Mandelboim O. et al. Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells. Nature. 2001; 409: 1055-1060 Crossref PubMed Scopus (750) Google Scholar demonstrated specific recognition of certain viral haemagglutinins by NKp46, one of the activating receptors of NK cells. Recognition involves a sialic acid on a carbohydrate group on NKp46 and is required for lysis of infected cells. However, other cellular receptors might also be involved.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.