Recognition of the threo and erythro isomers of 1-C-substituted glycerols

Abstract

A method for the differentiation of the threo and erythro isomers of 1-C-substituted glycerols has been developed, based on the difference in the chemical shift (Δδ) between the proton resonances of the two methyl groups of the corresponding isopropylidenes as a criterion of the location of the isopropylidene group on a polyol residue, as well as the regioselective formation of the isopropylidenes.