Abstract
Peptide nucleic acid is a synthetic DNA mimic in which the sugar-phosphate backbone has been replaced by a peptide backbone. A remarkable feature of PNA is its ability to recognize sequences within duplex DNA by strand invasion. We have previously demonstrated that a PNA targeting six bases within duplex DNA cooperatively binds to 12 base-pair site by strand invasion. We here report an successful extension of the target site size to 18 base pairs without the expense of specificity.
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