Abstract
Guinea pigs were immunized with DNP-mycobacteria prepared by reaction of the bacteria with dinitrofluorobenzene. T cells from these animals responded as well against DNPazo-proteins and proteins haptenated by reaction with DNP-sulfonic acid as against proteins haptenated by the same method as the immunogen. These cells responded also to free DNP- O-tyrosine, to the DNPazo derivatives of N-acetyltyrosine and of aminocaproic acid, and to α- N-DNP- l-asparagine. The experiments suggest that at least part of the DNP-responsive lymphocyte population found in animals primed with DNP-mycobacteria recognized a determinant no larger than the hapten with a single amino acid side chain, and that there was no requirement for the side chain to be aromatic (such as tyrosine or histidine) in order for recognition to occur. Determinants of this size were capable, in free form, of stimulating primed cells to mount an in vitro proliferative response. DNP-amino acids were not effective, however, as primary immunogens.
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