Abstract
The interactive recognition of nucleic acids by proteins is a central process in the regulation of gene expression. To gain insight into such interactions requires a knowledge of appropriate three-dimensional structures and information on biochemical function. Only a few native biological supramacromolecular protein-nucleic acid complexes are currently accessible for such detailed investigations. One convenient object for such study is the ternary complex composed of aminoacyl-tRNA (aa-tRNA) and elongation factor (EF-Tu) bound to GTR. This chapter brings up to date two earlier reviews addressing the problem of aa-tRNA and EF-Tu:GTP interaction. It summarizes the most recent published studies that contribute to an understanding of the recognitory interactions between tRNA and the protein elongation factor, and the chapter puts these studies in perspective. Finally, it proposes a new model for the three-dimensional structure of the ternary complex (TC). This model accommodates all existing structural experimental data obtained during the studies of the TC.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
