Abstract
Complex sleep apnea is a recently proposed classification category, describing patients with obstructive sleep apnea, who develop frequent central sleep apnea or periodic breathing pattern when treated with continuous positive airway pressure therapy. The prevalence of complex sleep apnea may be as high as 15% in a general sleep center patient population. The etiology of this syndrome is unclear, but a predominant derangement of respiratory control coexisting with upper airway obstruction has been proposed. Clinical significance is that these patients do not respond well to continuous positive airway pressure, and, in particular, may not be appropriate candidates for autotitrating devices. It would be useful to clinically identify such patients so that alternate therapeutic approaches could be anticipated.
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