Abstract
Reciprocity in breast cancer progression.
Highlights
Progression of solid tumors is characterized by an evolutive growing cellular mass containing variable proportions of a complex network of tumor stroma cell populations (TSC, about 30-70% in colon cancer) surrounding cancer cell (CC) foci
ECM remodeling during cancer progression is regulated by the concomitant secretion of CC and TSC soluble factors and cytokines as well as subcellular exosomes involved in genetic tranfer between cancer cells and their stromal microenvironment
Decorin protein core causes a longterm blockade or endocytosis of tyrosine kinase receptors (HER1, HER2, IGFR, MET), chemokine G-protein receptors CXCR4, LDL receptor-related protein (LRP1), and α2β1 integrins [2]. These decorin-dependent signal transduction systems are implicated in mitogenic and oncogenic functions connected with cancer cell adhesion, invasion, tumor angiogenesis and metastasis
Summary
Progression of solid tumors is characterized by an evolutive growing cellular mass containing variable proportions of a complex network of tumor stroma cell populations (TSC, about 30-70% in colon cancer) surrounding cancer cell (CC) foci. ECM remodeling during cancer progression is regulated by the concomitant secretion of CC and TSC soluble factors and cytokines as well as subcellular exosomes involved in genetic tranfer between cancer cells and their stromal microenvironment Several studies pointed the critical roles played by the ECM, CAF and MF in tumor progression.
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