Abstract
Reciprocity in breast cancer progression.
Highlights
Progression of solid tumors is characterized by an evolutive growing cellular mass containing variable proportions of a complex network of tumor stroma cell populations (TSC, about 30-70% in colon cancer) surrounding cancer cell (CC) foci
ECM remodeling during cancer progression is regulated by the concomitant secretion of CC and TSC soluble factors and cytokines as well as subcellular exosomes involved in genetic tranfer between cancer cells and their stromal microenvironment
Decorin protein core causes a longterm blockade or endocytosis of tyrosine kinase receptors (HER1, HER2, IGFR, MET), chemokine G-protein receptors CXCR4, LDL receptor-related protein (LRP1), and α2β1 integrins [2]. These decorin-dependent signal transduction systems are implicated in mitogenic and oncogenic functions connected with cancer cell adhesion, invasion, tumor angiogenesis and metastasis
Summary
Progression of solid tumors is characterized by an evolutive growing cellular mass containing variable proportions of a complex network of tumor stroma cell populations (TSC, about 30-70% in colon cancer) surrounding cancer cell (CC) foci. ECM remodeling during cancer progression is regulated by the concomitant secretion of CC and TSC soluble factors and cytokines as well as subcellular exosomes involved in genetic tranfer between cancer cells and their stromal microenvironment Several studies pointed the critical roles played by the ECM, CAF and MF in tumor progression.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
