Abstract
Somatostatin is reported to inhibit the proliferation of various kinds of cells, including lymphocytes, through its receptors ( 1 Chiba T. Yamada T. Gut somatostatin. in: Walsh J.H. Comprehensive Endocrinology. Gut Peptides. Raven Press, New York1994: 123-146 Google Scholar ). Octreotide, a somatostatin analogue, has been used for the treatment of lymphomas, although its effectiveness is unclear ( 2 Witzig T.E. Letendre L. Gerstner J. et al. Evaluation of a somatostatin analog in the treatment of lymphoproliferative disorders results of a phase II north central cancer treatment group trial. J Clin Oncol. 1995; 13: 2012-2015 Crossref PubMed Scopus (34) Google Scholar ). We have cared for a patient with a low-grade mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach accompanied by pancreatic somatostatinoma. Here we report that during the clinical course there were reciprocal changes in the plasma somatostatin concentration and the progression of the lymphoma, suggesting an inhibitory effect of plasma somatostatin on the proliferation of gastric MALT lymphoma.
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