Abstract
Osteosarcoma and ewing sarcoma are the two most common types of primary malignant bone tumors. Receptor tyrosine kinases (RTKs), including varieties of cell growth factors and proto-oncogene pro-ducts, are the high-affinity cell surface receptors which play an important role in the normal physiological function of cells. A large number of studies have demonstrated that the abnormal RTKs signaling pathways may promote the tumorigenesis and development of osteosarcoma and ewing sarcoma by affecting tumor cell survival, proliferation, invasion and metastasis. Targeting treatment of RTKs is a promising therapeutic approach for osteosarcoma and ewing sarcoma. Key words: Receptor protein-tyrosine kinases; Osteosarcoma; Sarcoma, Ewing′s; Drug therapy
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