Abstract
This Special Issue of Cells on receptor tyrosine kinases (RTKs) is a timely and unique assemblage of scholarly insights into topics that have relatively recently entered the spotlight in relation to this class of molecules. The review by Julien et al. [1] is an overview of the knowledge on how gangliosides, constituting certain membrane microdomains, may interact with and regulate RTK activation and downstream signalling. Similarly, the review by Banning et al. [2] focuses on the influence of another type of membrane microdomain, namely that containing flotillins, on regulation of RTK signalling and its relevance to cancer. Both of these reviews provide novel insights into mechanisms of transmembrane receptor signalling that rely on the constitution of the microdomains the RTKs reside in, and how their modification may affect receptor clustering, activation and translocation. Thus, knowledge about such microdomains and their interactions with RTKs can provide new information on common regulation pathways starting at the membrane level, which could have implications for novel therapeutic angles in, e.g., cancer. [...]
Highlights
This Special Issue of Cells on receptor tyrosine kinases (RTKs) is a timely and unique assemblage of scholarly insights into topics that have relatively recently entered the spotlight in relation to this class of molecules
The review by Brix et al [3] highlights the importance of one such RTK, the EGFR subfamily member ErbB2, in maintenance of a normal physiological state, as well as how it works in a detrimental manner in disease, such as promoting cell survival, proliferation and invasion of breast cancer cells
Away from the cell periphery, the processes regulating RTK activation, signal transduction and sorting and recycling inside the cell are topics of great interest that touch on other, distinct, aspects of RTK signalling
Summary
This Special Issue of Cells on receptor tyrosine kinases (RTKs) is a timely and unique assemblage of scholarly insights into topics that have relatively recently entered the spotlight in relation to this class of molecules. RTKs feature highly in cell proliferative and infiltrative diseases, such as cancer, it may be easy to forget that the presence and activity of RTKs is crucial to normal roles in cell and tissue development and homeostasis.
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